6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

Base Information

Chemical Name:6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil
CAS No.:928034-55-3
Molecular Formula:C₃₁H₃₆N₂O₇Si
Molecular Weight:576.722
Hs Code.:

Synonyms:6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

Chemical Property:

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Technology Process of 6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

There total 2 articles about 6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-hydroxymethyl-1-[6-(1-hydroxy-prop-2-ynyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione

: 58479-61-1
tert-butylchlorodiphenylsilane

: 928034-55-3
6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1002/hlca.200690259

Reference yield:

: 928034-54-2
1-[6,7-dideoxy-2,3-O-isopropylidene-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]-6-(hydroxymethyl)uracil

: 928034-55-3
6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 311 mg / Bu₄NF*3H₂O / tetrahydrofuran / 1 h

2: 476 mg / 1H-imidazole / dimethylformamide / 12 h / 25 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200690259

Reference yield: 98.0%

: 928034-62-2
8-iodo-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

: 928034-55-3
6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

: 928034-80-4
2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosin-8-yl-(8->7'-C)-6-{[(tert-butyl)diphenylsilyloxy]methyl}-1-(6,7-dideoxy-2,3-O-isopropylidene-α-L-talo-hept-6-ynofuranosyl)uracil

Guidance literature:: With copper(l) iodide; P(fur)3; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In triethylamine; toluene; at 26 ℃;
DOI:10.1002/hlca.200690259