methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

Base Information

Chemical Name:methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate
CAS No.:959991-77-6
Molecular Formula:C₃₀H₃₂Cl₂IN₃O₆
Molecular Weight:728.411
Hs Code.:

Synonyms:methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

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Chemical Property of methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

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Technology Process of methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

There total 4 articles about methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 959991-75-4
methyl N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

: 243640-97-3
tert-butyl 6-(2-hydroxyethyl)pyridin-2-yl(methyl)carbamate

: 959991-77-6
methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 938195-80-3
methyl N-(2,6-dichlorobenzoyl)-L-tyrosinate

: 959991-77-6
methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / N,N-dimethyl-formamide / 3.17 h / 0 - 20 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 48 h / 20 °C

With di-tert-butyl-diazodicarboxylate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 959991-77-6
methyl O-(2-{6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}ethyl)-N-(2,6-dichlorobenzoyl)-3-iodo-L-tyrosinate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4 - 20 °C

2: N,N,N-trimethylbenzenemethanaminium dichloroiodate / N,N-dimethyl-formamide / 3.17 h / 0 - 20 °C

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 48 h / 20 °C

With di-tert-butyl-diazodicarboxylate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 3: Mitsunobu reaction;