4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde

Base Information

• Chemical Name: 4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde
• CAS No.: 149399-91-7
• Molecular Formula: C₁₈H₂₅N₅O₆S
• Molecular Weight: 439.492

Synonyms:4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde

Chemical Property of 4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde

Chemical Property:

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Technology Process of 4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde

There total 1 articles about 4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-<<3-<3-<(2,5-dioxo-4-imidazolidinylidene)methyl>-4-nitrophenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde → 4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde (149399-91-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; for 43h; under 3102.9 Torr;

DOI:10.1021/jm00074a005

Reference yield:

4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde (149399-91-7) → 1-[[3-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]propyl]sulfonyl]-4-(2-cyclohexylethyl)piperazine

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / p-TsOH / methanol / 6 h / Heating

2: 98 percent / I₂ / dimethylformamide / 1 h / 100 - 110 °C

3: 96 percent / 1 N aq. NaOH / methanol / 23 h / Heating

4: Et₃N / dimethylformamide

With sodium hydroxide; iodine; toluene-4-sulfonic acid; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00074a005

Reference yield:

4-<<3-<4-amino-3-<(2,5-dioxo-4-imidazolidinyl)methyl>phenoxy>propyl>sulfonyl>-1-piperazinecarboxaldehyde (149399-91-7) → 1-[[3-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]propyl]sulfonyl]-4-[(3-trifluoromethylphenyl)methyl]piperazine

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / p-TsOH / methanol / 6 h / Heating

2: 98 percent / I₂ / dimethylformamide / 1 h / 100 - 110 °C

3: 96 percent / 1 N aq. NaOH / methanol / 23 h / Heating

4: Et₃N / dimethylformamide

With sodium hydroxide; iodine; toluene-4-sulfonic acid; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00074a005

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