5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide

Base Information

• Chemical Name: 5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide
• CAS No.: 1395397-23-5
• Molecular Formula: C₂₁H₃₃N₃O₃
• Molecular Weight: 375.511
• Mol file: 1395397-23-5.mol

Synonyms:5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide

Chemical Property of 5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide

There total 4 articles about 5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + C16H23IN2O3 → 5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide (1395397-23-5)

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Reflux;

DOI:10.1016/j.bmc.2012.06.026

Reference yield:

N-butyl-2-isopropoxy-5-nitrobenzamide (1395395-98-8) → 5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide (1395397-23-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; water / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane; water / 3 h / -10 - 20 °C

3: sodium iodide / acetonitrile / 0.5 h / Reflux

4: potassium carbonate / acetonitrile / 4 h / Reflux

With sodium tetrahydroborate; palladium 10% on activated carbon; potassium carbonate; triethylamine; sodium iodide; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/j.bmc.2012.06.026

Reference yield:

2-chloro-5-nitrobenzoic acid (2516-96-3) → 5-(2-(piperidin-1-yl)acetamido)-N-butyl-2-isopropoxybenzamide (1395397-23-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

3.1: sodium hydride / 1,4-dioxane; mineral oil / 2 h / 70 °C / Cooling with ice; Inert atmosphere

3.2: 4 h / 70 °C / Inert atmosphere

4.1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; water / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane; water / 3 h / -10 - 20 °C

6.1: sodium iodide / acetonitrile / 0.5 h / Reflux

7.1: potassium carbonate / acetonitrile / 4 h / Reflux

With sodium tetrahydroborate; palladium 10% on activated carbon; sodium hydride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

DOI:10.1016/j.bmc.2012.06.026

upstream raw materials:

piperidine

5-(2-bromoacetamido)-N-butyl-2-isopropoxybenzamide

N-butyl-2-isopropoxy-5-nitrobenzamide

2-chloro-5-nitrobenzoic acid