4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

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Chemical Name:4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile
CAS No.:1340595-73-4
Molecular Formula:C₂₀H₁₅N₅O₂
Molecular Weight:357.371
Hs Code.:

Synonyms:4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

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Chemical Property of 4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

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Technology Process of 4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

There total 4 articles about 4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1340596-11-3
C₁₃H₁₂N₄O₂

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1340595-73-4
4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:: With copper(II) acetate monohydrate; triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.08.060

Reference yield:

: 1340595-96-1
4-(6-chloropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

: 1340595-73-4
4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 6 h / 120 °C

2.1: sodium hydride / 1,4-dioxane / 1 h / 60 °C

2.2: 24 h / 20 - 60 °C

3.1: copper(II) acetate monohydrate; triethylamine / dichloromethane / 2 h / 20 °C

With copper(II) acetate monohydrate; sodium hydride; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.08.060

Reference yield:

: 1340596-00-0
3,5-dimethyl-4-(6-oxo-1,6-dihydropyridazin-3-yloxy)benzonitrile

: 1340595-73-4
4-(1-(3-cyanophenylamino)-6-oxo-1,6-dihydropyridazin-3-yloxy)-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,4-dioxane / 1 h / 60 °C

1.2: 24 h / 20 - 60 °C

2.1: copper(II) acetate monohydrate; triethylamine / dichloromethane / 2 h / 20 °C

With copper(II) acetate monohydrate; sodium hydride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.08.060