tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
CAS No.:1261173-15-2
Molecular Formula:C₃₂H₃₄N₄O₃
Molecular Weight:522.647
Hs Code.:

Synonyms:tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Suppliers and Price of tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

There total 6 articles about tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956904-27-1
3-cyano-4-cyclohexylbenzoic acid

: 1174512-15-2
tert-butyl 2-(7-(N'-hydroxycarbamimidoyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 1261173-15-2
tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: 3-cyano-4-cyclohexylbenzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl acetamide; at 60 ℃; for 1h;

tert-butyl 2-(7-(N'-hydroxycarbamimidoyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate; In N,N-dimethyl acetamide; at 90 ℃; for 3h;

Reference yield:

: 16732-70-0
ethyl 5-bromoindolecarboxylate

: 1261173-15-2
tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / toluene; mineral oil / 48 h / 110 °C

2.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C / Sealed tube; Microwave irradiation

3.1: tetrahydrofuran / 22 h / 65 °C

4.1: hydrogen / palladium on carbon / ethyl acetate / 22 h / 3620.13 Torr / Inert atmosphere

5.1: hydroxylamine / ethanol; water / 4 h / 70 °C / Sealed tube

6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide / 1 h / 60 °C

6.2: 3 h / 90 °C

With 1-methyl-pyrrolidin-2-one; hydrogen; hydroxylamine; sodium hydride; 1,1'-carbonyldiimidazole; palladium on carbon; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; ethyl acetate; toluene; mineral oil;

Reference yield:

: 1174512-53-8
7-bromo-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one

: 1261173-15-2
tert-butyl 2-(7-(5-(3-cyano-4-cyclohexyl-phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C / Sealed tube; Microwave irradiation

2.1: tetrahydrofuran / 22 h / 65 °C

3.1: hydrogen / palladium on carbon / ethyl acetate / 22 h / 3620.13 Torr / Inert atmosphere

4.1: hydroxylamine / ethanol; water / 4 h / 70 °C / Sealed tube

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide / 1 h / 60 °C

5.2: 3 h / 90 °C

With 1-methyl-pyrrolidin-2-one; hydrogen; hydroxylamine; 1,1'-carbonyldiimidazole; palladium on carbon; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; ethyl acetate;