(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride

Base Information

Chemical Name:(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride
CAS No.:1335122-56-9
Molecular Formula:C₁₈H₂₂IN₃O₃*ClH
Molecular Weight:491.756
Hs Code.:

Synonyms:(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride

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Chemical Property of (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride

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Technology Process of (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride

There total 8 articles about (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1335122-61-6
C₂₈H₃₈IN₃O₇

: 1335122-56-9
(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-57-9
tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-56-9
(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate

5: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water

6: hydrogenchloride / ethyl acetate / 8 h / 20 °C

With hydrogenchloride; sodium azide; iron(III) chloride hexahydrate; pyrographite; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; potassium iodide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1335122-75-2
C₂₈H₄₀N₄O₇

: 1335122-56-9
(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-3-(4-hydroxyphenyl)propanamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water

2: hydrogenchloride / ethyl acetate / 8 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In water; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.008