di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate

Base Information

Chemical Name:di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate
CAS No.:874964-40-6
Molecular Formula:C₂₅H₃₅N₅O₅S
Molecular Weight:517.649
Hs Code.:

Synonyms:di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate

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Chemical Property of di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate

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Technology Process of di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate

There total 5 articles about di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 874900-79-5
N-{4-[3-(4-aminophenyl)propyl]-1,3-thiazol-2-yl}acetamide

: 152120-54-2,862686-58-6,1143572-00-2
N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

: 874964-40-6
di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 14h;
DOI:10.1016/j.bmc.2012.12.025

Reference yield:

: 1426055-76-6
4-[3-(4-nitrophenyl)propyl]-1,3-thiazol-2-amine

: 874964-40-6
di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen; acetic acid / methanol; tetrahydrofuran / 5 h / 20 °C / 2280.15 Torr

3: tetrahydrofuran / 14 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.12.025

Reference yield:

: 183365-27-7
N-{4-[3-(4-nitrophenyl)propyl]-1,3-thiazol-2-yl}acetamide

: 874964-40-6
di-tert-butyl {(Z)-[(4-{3-[2-(acetylamino)-1,3-thiazol-4-yl]propyl}phenyl)amino]methylidene}biscarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol; tetrahydrofuran / 5 h / 20 °C / 2280.15 Torr

2: tetrahydrofuran / 14 h / 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2012.12.025