Technology Process of APS-999
There total 20 articles about APS-999 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide; triethylamine;
In
1-methyl-pyrrolidin-2-one;
at 150 ℃;
for 80h;
DOI:10.1016/j.bmcl.2011.09.004
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / -20 °C
2: methanol; sodium methylate / 20 °C
3: 1H-imidazole / N,N-dimethyl-formamide / 60 °C
4: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C
5: oxalyl dichloride / dichloromethane / 20 °C
6: ammonia / chloroform / 0 °C
7: pyridine / 20 °C
8: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
9: sodium azide; triethylamine / 1-methyl-pyrrolidin-2-one / 80 h / 150 °C
With
pyridine; 1H-imidazole; methanol; sodium tetrahydroborate; sodium azide; oxalyl dichloride; cerium(III) chloride heptahydrate; tetrabutyl ammonium fluoride; ammonia; water; sodium methylate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
9: Prins reaction;
DOI:10.1016/j.bmcl.2011.09.004
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 60 °C
2: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C
3: oxalyl dichloride / dichloromethane / 20 °C
4: ammonia / chloroform / 0 °C
5: pyridine / 20 °C
6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
7: sodium azide; triethylamine / 1-methyl-pyrrolidin-2-one / 80 h / 150 °C
With
pyridine; 1H-imidazole; sodium azide; oxalyl dichloride; tetrabutyl ammonium fluoride; ammonia; water; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
7: Prins reaction;
DOI:10.1016/j.bmcl.2011.09.004
