tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Base Information

Chemical Name:tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate
CAS No.:1365758-90-2
Molecular Formula:C₁₈H₁₈ClN₃O₆
Molecular Weight:407.81
Hs Code.:

Synonyms:tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

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Chemical Property of tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

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Technology Process of tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

There total 4 articles about tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1008510-46-0
2-methyl-4,6-dioxopiperidine-1-carboxylic acid tert-butyl ester

: 880474-09-9
C₇H₄Cl₂N₂O₃

: 1365758-90-2
tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: 2-methyl-4,6-dioxopiperidine-1-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; Combinatorial reaction / High throughput screening (HTS);

C₇H₄Cl₂N₂O₃; In tetrahydrofuran; Combinatorial reaction / High throughput screening (HTS);
DOI:10.1021/co200200u

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1365758-90-2
tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

3.1: ethyl acetate / 4 h / Reflux

4.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)

4.2: Combinatorial reaction / High throughput screening (HTS)

With dmap; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/co200200u

Reference yield:

: 43080-09-7,52815-19-7
3-t-butoxycarbonylaminobutyric acid

: 1365758-90-2
tert-butyl 3-(5-chloro-2-nitrophenyl)-6-methyl-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2.1: ethyl acetate / 4 h / Reflux

3.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)

3.2: Combinatorial reaction / High throughput screening (HTS)

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/co200200u