4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid

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Chemical Name:4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid
CAS No.:1361449-69-5
Molecular Formula:C₂₄H₂₂BrN₅O₃
Molecular Weight:508.374
Hs Code.:

Synonyms:4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid

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Chemical Property of 4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid

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Technology Process of 4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid

There total 9 articles about 4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-25-2
Bromoform

: 1361450-95-4
4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone

: 1361449-69-5
4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid

Guidance literature:: With potassium hydroxide; In water; acetonitrile; at 20 ℃; Cooling with ice;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1361449-69-5
4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 - 0 °C

3.1: acetic acid / 100 °C / sealed tube

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

5.1: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; tert-butyl alcohol / 20 °C

6.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

7.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

8.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.5 h / 20 °C

9.1: potassium hydroxide / acetonitrile; water / 20 °C / Cooling with ice

With 2,6-dimethylpyridine; potassium phosphate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; n-butyllithium; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; lithium diisopropyl amide; osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 145576-28-9
ethyl 4-methylidenecyclohexanecarboxylate

: 1361449-69-5
4-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-hydroxycyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 - 0 °C

2.1: acetic acid / 100 °C / sealed tube

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

4.1: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; tert-butyl alcohol / 20 °C

5.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

6.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

7.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.5 h / 20 °C

8.1: potassium hydroxide / acetonitrile; water / 20 °C / Cooling with ice

With 2,6-dimethylpyridine; potassium phosphate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; n-butyllithium; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; tert-butyl alcohol;