(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate

Base Information

Chemical Name:(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate
CAS No.:1079392-84-9
Molecular Formula:C₂₆H₂₅N₃O₅
Molecular Weight:459.502
Hs Code.:

Synonyms:(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate

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Chemical Property of (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate

Chemical Property:

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Technology Process of (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate

There total 3 articles about (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1079392-91-8
C₃₅H₄₅N₃O₅Si

: 1079392-84-9
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate

Guidance literature:: With hydrogen fluoride; In water; acetonitrile; at 0 ℃; for 0.166667h;
DOI:10.1039/b807640e

Reference yield:

: 130-95-0
Quinine

: 1079392-84-9
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium thioethylate / N,N-dimethyl-formamide / 24 h / 105 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; triethylamine; sodium thioethylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201701224

Reference yield:

: 876269-53-3
C₂₈H₄₂N₂O₂Si

: 1079392-84-9
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/adsc.201701224