(S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole

Base Information

Chemical Name:(S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole
CAS No.:882490-35-9
Molecular Formula:C₂₈H₂₈NPS
Molecular Weight:441.577
Hs Code.:

Synonyms:(S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole

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Chemical Property of (S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole

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Technology Process of (S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole

There total 12 articles about (S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole borane adduct

: 882490-35-9
(S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole

Guidance literature:: With diethylamine; at 20 ℃;
DOI:10.1021/ja057178b

Reference yield:

: 882490-29-1
(S)-(2-bromo-4,5,6,7-tetrahydrobenzo[d]thiazol-4-yl)methanol

: 882490-35-9
(S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / PdCl₂*dppf*CHCl₃; aq. Na₂CO₃ / toluene / 2 h / 80 °C

2.1: 79 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

3.2: 79 percent / tetrahydrofuran; dimethylformamide; hexane / 20 °C

4.1: 93 percent / Et₂NH / 20 °C

With pyridine; n-butyllithium; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; sodium carbonate; diethylamine; In tetrahydrofuran; hexane; dichloromethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/ja057178b

Reference yield:

: 882490-28-0
ethyl (S)-2-bromo-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate

: 882490-35-9
(S)-4-((di-o-tolylphosphino)methyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 72 percent / DIBAL / tetrahydrofuran; toluene / 1 h / -40 °C

2.1: 86 percent / PdCl₂*dppf*CHCl₃; aq. Na₂CO₃ / toluene / 2 h / 80 °C

3.1: 79 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

4.2: 79 percent / tetrahydrofuran; dimethylformamide; hexane / 20 °C

5.1: 93 percent / Et₂NH / 20 °C

With pyridine; n-butyllithium; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; diisobutylaluminium hydride; sodium carbonate; diethylamine; In tetrahydrofuran; hexane; dichloromethane; toluene; 2.1: Suzuki coupling;
DOI:10.1021/ja057178b