(+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Base Information

Chemical Name:(+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine
CAS No.:172467-63-9
Molecular Formula:C₁₈H₁₅NO₂S
Molecular Weight:309.389
Hs Code.:

Synonyms:(+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

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Technology Process of (+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

There total 5 articles about (+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 43153-79-3
4H-pyrrolo<2,1-c><1,4>benzothiazin-4-one

: 104-92-7
1-bromo-4-methoxy-benzene

: 172467-63-9
(+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Guidance literature:: In tetrahydrofuran; diethyl ether; at 40 ℃; for 2h;
DOI:10.1021/jm00022a005

Reference yield:

: 43153-83-9
N-(2-methylthiophenyl)pyrrole

: 172467-63-9
(+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 2,6-lutidine / 1.) dioxane, reflux, 3 h, 2.) EtOH, RT, 30 h

2: 94 percent / KOH / ethanol; tetrahydrofuran / 20 h / 60 °C

3: 67 percent / thionyl chloride / benzene / 2 h / Heating

4: 46 percent / aluminum chloride / benzene / 24 h / Ambient temperature

5: 67 percent / tetrahydrofuran; diethyl ether / 2 h / 40 °C

With 2,6-dimethylpyridine; potassium hydroxide; aluminium trichloride; thionyl chloride; In tetrahydrofuran; diethyl ether; ethanol; benzene;
DOI:10.1021/jm00022a005

Reference yield:

: 172467-34-4
N-<2'-(methylthio)phenyl>pyrrole-2-carboxylic acid

: 172467-63-9
(+/-)-4-hydroxy-4-(p-methoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / thionyl chloride / benzene / 2 h / Heating

2: 46 percent / aluminum chloride / benzene / 24 h / Ambient temperature

3: 67 percent / tetrahydrofuran; diethyl ether / 2 h / 40 °C

With aluminium trichloride; thionyl chloride; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/jm00022a005