2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine

Base Information

Chemical Name:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine
CAS No.:1362910-77-7
Molecular Formula:C₂₃H₁₆F₃N₇
Molecular Weight:447.422
Hs Code.:

Synonyms:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine

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Chemical Property of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine

There total 6 articles about 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 31230-17-8
3-methyl-5-aminopyrazole

: 1362910-90-4
2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)-7-(pyrimidin-5-yl)quinazoline

: 1362910-77-7
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine

Guidance literature:: 2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)-7-(pyrimidin-5-yl)quinazoline; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;

3-methyl-5-aminopyrazole; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 94010-78-3
2,2-difluoro-2-(4-fluorophenyl)acetic acid

: 1362910-77-7
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trimethylsilyl polyphosphate / 130 °C

2.1: Lawessons reagent / toluene / 100 °C

3.1: potassium carbonate / ethanol / 1.5 h / 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

5.2: 1 h / 20 °C

With Lawessons reagent; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 112253-70-0
2-amino-4-bromobenzamide

: 1362910-77-7
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(pyrimidin-5-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trimethylsilyl polyphosphate / 130 °C

2.1: Lawessons reagent / toluene / 100 °C

3.1: potassium carbonate / ethanol / 1.5 h / 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

5.2: 1 h / 20 °C

With Lawessons reagent; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; water; toluene; acetonitrile;