2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

Base Information

Chemical Name:2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid
CAS No.:1265399-79-8
Molecular Formula:C₂₂H₂₁ClN₂O₃
Molecular Weight:396.873
Hs Code.:

Synonyms:2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

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Chemical Property of 2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

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Technology Process of 2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

There total 7 articles about 2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.5%

: 1265399-74-3
2-(4-(4-chloro-2-methoxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

: 1265399-79-8
2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

Guidance literature:: 2-(4-(4-chloro-2-methoxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 17h;

With water; In dichloromethane;

Reference yield:

: 615-83-8
2-bromo-pentanoic acid ethyl ester

: 1265399-79-8
2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2.1: sodium methylate; methanol / 18 h / Reflux

3.1: thionyl chloride / 18 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 3 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2.5 h / Sealed tube

6.1: sodium hydroxide; methanol / 18 h / 60 °C / Sealed tube

6.2: pH 2 - 3

7.1: boron tribromide / dichloromethane / 17 h / -78 - 20 °C

With methanol; thionyl chloride; sodium methylate; boron tribromide; potassium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1265397-22-5
methyl 2-(4-chloro-6-methyl-2-phenylpyrimidin-5-yl)pentanoate

: 1265399-79-8
2-(4-(4-chloro-2-hydroxyphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2.5 h / Sealed tube

2.1: sodium hydroxide; methanol / 18 h / 60 °C / Sealed tube

2.2: pH 2 - 3

3.1: boron tribromide / dichloromethane / 17 h / -78 - 20 °C

With methanol; boron tribromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;