2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran

Base Information

• Chemical Name: 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran
• CAS No.: 102612-19-1
• Molecular Formula: C₂₁H₂₄O₃
• Molecular Weight: 324.42
• Mol file: 102612-19-1.mol

Synonyms:2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran

Chemical Property of 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran

There total 10 articles about 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran (102625-14-9) → 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran (102612-19-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.166667h; Heating;

DOI:10.1021/jm00126a008

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran (102612-19-1)

Guidance literature:

Multi-step reaction with 7 steps

1: K₂CO₃ / acetone / Heating

2: 37 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: K₂CO₃

4: various solvent(s) / Heating

5: H₂ / Pd/C

6: 95 percent / CH₂Cl₂ / 20 h / Ambient temperature

7: 91 percent / NaBH₄ / ethanol / 0.17 h / Heating

With sodium tetrahydroborate; hydrogen; sodium cyanoborohydride; potassium carbonate; zinc(II) iodide; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetone;

DOI:10.1021/jm00126a008

Reference yield:

2,6-dihydroxylacetophenone (699-83-2) → 2-(p-methoxybenzyl)-3,7-dimethyl-4-hydroxy-5-propylbenzofuran (102612-19-1)

Guidance literature:

Multi-step reaction with 7 steps

1: K₂CO₃ / acetone / Heating

2: 37 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: K₂CO₃

4: various solvent(s) / Heating

5: H₂ / Pd/C

6: 95 percent / CH₂Cl₂ / 20 h / Ambient temperature

7: 91 percent / NaBH₄ / ethanol / 0.17 h / Heating

With sodium tetrahydroborate; hydrogen; sodium cyanoborohydride; potassium carbonate; zinc(II) iodide; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetone;

DOI:10.1021/jm00126a008

upstream raw materials:

4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

2,6-dihydroxylacetophenone

2,6-dihydroxy-5-propyl acetophenone

2-(p-methoxybenzyl)-3-methyl-4-hydroxybenzofuran