methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Base Information

• Chemical Name: methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate
• CAS No.: 1393593-35-5
• Molecular Formula: C₂₁H₂₆ClNO₂
• Molecular Weight: 359.896

Synonyms:methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Chemical Property of methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Chemical Property:

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Technology Process of methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate

There total 2 articles about methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-N-(3′-chloropropyl)-N-(α-methylbenzyl)amine (1393593-20-8) + methyl cinnamate (103-26-4,1754-62-7) → methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-35-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1021/jo3012732

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 16 h / 20 °C

2: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

With n-butyllithium; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo3012732

Reference yield: 78.0%

methyl (3S, αR)-3-[N-( 3'-chloropropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-35-5) → methyl (3S, αR)-3-[N-( 3'-azidopropyl)-N-(α-methylbenzyl)amino]-3-phenylpropanoate (1393593-36-6)

Guidance literature:

With sodium azide; sodium iodide; In dimethyl sulfoxide; at 50 ℃; for 24h;

DOI:10.1021/jo3012732

upstream raw materials:

(R)-N-(3′-chloropropyl)-N-(α-methylbenzyl)amine

methyl cinnamate

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

methyl (S)-3-[N-(3'-chloropropyl)-N-methylamino]-3-phenylpropanoate

methyl (S)-3-[N-(3'-azidopropyl)-N-methylamino]-3-phenylpropanoate

C₁₄H₂₂N₂O₂

methyl (S)-3-(3'-chloropropylamino)-3-phenylpropanoate

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