(2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Base Information

Chemical Name:(2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide
CAS No.:176198-66-6
Molecular Formula:C₁₆H₂₅NO₃
Molecular Weight:279.379
Hs Code.:

Synonyms:(2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Technology Process of (2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

There total 4 articles about (2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 175979-70-1
(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: 176198-66-6
(2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.25h;
DOI:10.1021/jo952032o

Reference yield:

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 176198-66-6
(2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium N,N-diisopropylamide, lithium chloride / 1.) THF, -78 -> 23 deg C, 2.) THF, 45 deg C, 14 h

2: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h

With tetrabutyl ammonium fluoride; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo952032o

Reference yield:

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 15448-47-2
(R)-propylene oxide

: 176198-66-6
(2R,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: (2S,4R)-4-Hydroxy-2-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: With (S)-Propylene oxide; lithium chloride; lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 -> 23 deg C, 2.) THF, -5 deg C, 6 h;
DOI:10.1021/jo952032o