(R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:(R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester
CAS No.:519021-27-3
Molecular Formula:C₃₇H₄₃N₃O₈S₂
Molecular Weight:721.896
Hs Code.:

(R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

Synonyms:(R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

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Chemical Property of (R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

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Technology Process of (R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

There total 10 articles about (R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 519021-26-2
(R)-2-[1-amino-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

: 519021-21-7
(R)-2-benzyloxycarbonylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionic acid

: 519021-27-3
(R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃;

Reference yield:

: 519021-19-3
(R)-2-benzyloxycarbonylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionic acid methyl ester

: 519021-27-3
(R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / LiOH; H₂O / tetrahydrofuran / 20 h

2: 92 percent / DIPEA; DMAP; PyBroP / CH₂Cl₂ / 0 - 20 °C

3: acetic anhydride / dimethylsulfoxide

4: triphenylphosphine; iodine; Et₃N / CH₂Cl₂

5: 96 percent / HBr; AcOH / CH₂Cl₂ / 0 - 20 °C

6: 56 percent / DIPEA; DMAP; PyBroP / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; water; hydrogen bromide; iodine; acetic anhydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 135923-86-3,135923-87-4,143564-89-0
(2R,4R)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one

: 519021-27-3
(R,R)-2-[1-[2-isobutyrylamino-3-(4-methoxybenzylsulfanyl)-2-methylpropionylamino]-2-(4-methoxybenzylsulfanyl)-1-methylethyl]-5-methyloxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / HMPA; LHMDS / tetrahydrofuran / -78 °C

2: 85 percent / NaOMe; MeOH / tetrahydrofuran / 3 h / -40 - -20 °C

3: 100 percent / Ag₂O / acetonitrile / 0.5 h / Heating

4: 46 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h

5: 97 percent / LiOH; H₂O / tetrahydrofuran / 20 h

6: 56 percent / DIPEA; DMAP; PyBroP / CH₂Cl₂ / 20 °C

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium hydroxide; boron trifluoride diethyl etherate; water; sodium methylate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;