(2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

Base Information

Chemical Name:(2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene
CAS No.:189456-83-5
Molecular Formula:C₂₉H₄₀N₂O₅
Molecular Weight:496.647
Hs Code.:

Synonyms:(2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

Suppliers and Price of (2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

There total 17 articles about (2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 189456-88-0
[1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

: 189456-83-5
(2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

Guidance literature:: With sodium; In tetrahydrofuran; ammonia; at -33 ℃; for 1h;
DOI:10.1016/S0040-4020(97)00160-9

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 189456-83-5
(2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / tetrahydrofuran; H₂O / 2 h / 20 °C

2.1: 81 percent / LiBH₄ / tetrahydrofuran / 3 h / 20 °C

3.1: 85 percent / sulfur trioxide pyridine complex; Et₃N / dimethylsulfoxide / 1 h / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran / -78 °C

4.2: MeOH; DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.1: pyridine / CH₂Cl₂ / 12 h / 20 °C

6.1: 0.94 g / Na₂HPO₄; Na-Hg / methanol / 12 h / 0 - 20 °C

7.1: 65 percent / sodium / liquid ammonia; tetrahydrofuran / 1 h / -33 °C

With pyridine; disodium hydrogenphosphate; lithium borohydride; n-butyllithium; sodium amalgam; sodium; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; methanol; dichloromethane; ammonia; water; dimethyl sulfoxide; 1.1: alkoxycarbonylation / 2.1: Reduction / 3.1: Oxidation / 4.1: Metallation / 4.2: Addition / 5.1: Acetylation / 6.1: Elimination / 7.1: debenzylation;
DOI:10.1016/S0040-4020(97)00160-9

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 189456-83-5
(2S,5S,3E)-2,5-bis[(1,1-dimethylethoxy)-carbonyl]amino-1-phenyl-6-(p-methoxy)phenylhex-3-ene

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaBH₄; I₂ / tetrahydrofuran / 18 h / Heating

2.1: 95 percent / tetrahydrofuran; H₂O / 1 h / 20 °C

3.1: 90 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 83 percent / methanol; tetrahydrofuran / 3 h / 20 °C

5.1: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 20 °C

6.1: n-BuLi / tetrahydrofuran / -78 °C

6.2: MeOH; DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C

7.1: pyridine / CH₂Cl₂ / 12 h / 20 °C

8.1: 0.94 g / Na₂HPO₄; Na-Hg / methanol / 12 h / 0 - 20 °C

9.1: 65 percent / sodium / liquid ammonia; tetrahydrofuran / 1 h / -33 °C

With pyridine; sodium tetrahydroborate; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; iodine; sodium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; ammonia; water; 1.1: Reduction / 2.1: alkoxycarbonylation / 3.1: Tosylation / 4.1: Substitution / 5.1: Oxidation / 6.1: Metallation / 6.2: Addition / 7.1: Acetylation / 8.1: Elimination / 9.1: debenzylation;
DOI:10.1016/S0040-4020(97)00160-9