Alletorphine

Base Information

• Chemical Name: Alletorphine
• CAS No.: 23758-80-7
• Molecular Formula: C₂₇H₃₅NO₄
• Molecular Weight: 437.579
• Mol file: 23758-80-7.mol

Synonyms:6,14-Ethenomorphinan-7-methanol,4,5-epoxy-3-hydroxy-6-methoxy-a-methyl-17-(2-propenyl)-a-propyl-, [5a,7a(R)]-;6,14-endo-Ethenotetrahydrooripavine, 17-allyl-17-demethyl-7a-((R)-1-hydroxy-1-methylbutyl)-(8CI);Alletorphine;N-Allylnoretorphine;R&;S 218M;RX 218M;

Chemical Property of Alletorphine

Chemical Property:

• Refractive Index: 1.642
• PSA: 62.16000
• LogP: 3.65770

Purity/Quality:

95% ^*data from raw suppliers

ALLETORPHINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Alletorphine

There total 3 articles about Alletorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5α-epoxy-19anti-((R)-1-hydroxy-1-methyl-butyl)-3,6-dimethoxy-6β,14-ethano-morphin-7-ene-17-carbonitrile (16549-51-2) → Alletorphine (23758-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / bis-(2-hydroxy-ethyl) ether / 200 - 220 °C

2: K₂CO₃ / ethanol / Heating

With potassium hydroxide; potassium carbonate; In ethanol; diethylene glycol;

DOI:10.1021/ja00989a032

Reference yield:

4,5α-epoxy-19anti-((R)-1-hydroxy-1-methyl-butyl)-6-methoxy-6β,14-ethano-morphin-7-en-3-ol (16550-28-0) + allyl bromide (106-95-6) → Alletorphine (23758-80-7)

Guidance literature:

With potassium carbonate; In ethanol; Heating;

DOI:10.1021/ja00989a032

Reference yield:

→ 17-allyl-4,5α-epoxy-19anti-((R)-1-hydroxy-1-methyl-butyl)-6-methoxy-6β,14-ethano-morphin-7-en-3-ol (18978-35-3,23758-80-7)

Guidance literature:

Enamin (2b),T2O ,NaBH4;

DOI:10.1021/jm00250a023

upstream raw materials:

4,5α-epoxy-19anti-((R)-1-hydroxy-1-methyl-butyl)-6-methoxy-6β,14-ethano-morphin-7-en-3-ol

allyl bromide

4,5α-epoxy-19anti-((R)-1-hydroxy-1-methyl-butyl)-3,6-dimethoxy-6β,14-ethano-morphin-7-ene-17-carbonitrile

Refernces