2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

Base Information

Chemical Name:2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester
CAS No.:786704-02-7
Molecular Formula:C₂₁H₂₃N₃O₅
Molecular Weight:397.431
Hs Code.:

Synonyms:2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

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Chemical Property of 2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

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Technology Process of 2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

There total 4 articles about 2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 27326-43-8
2-vinylbenzoic acid

: 786704-01-6
2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester

: 786704-02-7
2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

Guidance literature:: 2-vinylbenzoic acid; With oxalyl dichloride; In dichloromethane; for 1h;

2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester; In tetrahydrofuran; for 8h;
DOI:10.1021/jo047834a

Reference yield:

: 168779-59-7
3-ethyl-2-oxo-piperidine-3-carboxylic acid

: 786704-02-7
2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 12 h / 20 °C

1.2: 61 percent / isopropyl magnesium chloride / tetrahydrofuran / 12 h / 20 °C

2.1: 76 percent / triethylamine; mesyl azide / acetonitrile / 10 h / 25 °C

3.1: oxalyl chloride / CH₂Cl₂ / 1 h

3.2: 70 percent / 4 Angstroem molecular sieves / tetrahydrofuran / 8 h

With oxalyl dichloride; triethylamine; Methanesulfonyl azide; 1,1'-carbonyldiimidazole; In dichloromethane; acetonitrile;
DOI:10.1021/ol048915w

Reference yield:

: 786704-00-5
3-(3-ethyl-2-oxopiperidin-3-yl)-3-oxopropionic acid ethyl ester

: 786704-02-7
2-diazo-3-[3-ethyl-2-oxo-1-(2-vinyl-benzoyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / triethylamine; mesyl azide / acetonitrile / 10 h / 25 °C

2.1: oxalyl chloride / CH₂Cl₂ / 1 h

2.2: 70 percent / 4 Angstroem molecular sieves / tetrahydrofuran / 8 h

With oxalyl dichloride; triethylamine; Methanesulfonyl azide; In dichloromethane; acetonitrile;
DOI:10.1021/ol048915w