2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Base Information

Chemical Name:2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid
CAS No.:1613082-62-4
Molecular Formula:C₁₆H₁₀F₂N₄O₅
Molecular Weight:376.276
Hs Code.:

Synonyms:2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

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Chemical Property of 2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

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Technology Process of 2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

There total 4 articles about 2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1613082-61-3
2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid methyl ester

: 1613082-62-4
2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2014.04.047

Reference yield:

: 1374748-46-5
methyl 2-(3-((2,4-difluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate

: 1613082-62-4
2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) nitrate trihydrate; acetic anhydride / dichloromethane / 12 h / 20 °C

2: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With copper(II) nitrate trihydrate; water; acetic anhydride; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.04.047

Reference yield:

: 35676-70-1
3-chloro-quinoxaline-2(1H)-one

: 1613082-62-4
2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 2 h / 55 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 75 °C

3: copper(II) nitrate trihydrate; acetic anhydride / dichloromethane / 12 h / 20 °C

4: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With copper(II) nitrate trihydrate; water; acetic anhydride; potassium carbonate; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2014.04.047