Technology Process of C24H24F2N4O4S*ClH
There total 6 articles about C24H24F2N4O4S*ClH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C31H32F2N4O5S;
With
trifluoroacetic acid;
at 20 ℃;
for 0.833333h;
With
hydrogenchloride;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene; chloroform / 0.5 h / 20 °C
2.2: 0.42 h / -78 °C / Inert atmosphere
2.3: 2 h / 100 °C
3.1: formic acid / 5 h / 20 °C
4.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; HATU / N,N-dimethyl-formamide / 20 °C / Cooling with ice
5.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C
5.2: 12 h / 100 °C
6.1: trifluoroacetic acid / 0.83 h / 20 °C
With
hydrogenchloride; formic acid; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; triethylamine; HATU; trifluoroacetic acid;
N,N-dimethyl-formamide;
In
1,4-dioxane; chloroform; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene; chloroform / 0.5 h / 20 °C
1.2: 0.42 h / -78 °C / Inert atmosphere
1.3: 2 h / 100 °C
2.1: formic acid / 5 h / 20 °C
3.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; HATU / N,N-dimethyl-formamide / 20 °C / Cooling with ice
4.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C
4.2: 12 h / 100 °C
5.1: trifluoroacetic acid / 0.83 h / 20 °C
With
hydrogenchloride; formic acid; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; triethylamine; HATU; trifluoroacetic acid;
N,N-dimethyl-formamide;
In
1,4-dioxane; chloroform; N,N-dimethyl-formamide; toluene;