(2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide

Base Information

Chemical Name:(2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide
CAS No.:119593-41-8
Molecular Formula:C₁₅H₂₁NO₄S
Molecular Weight:311.402
Hs Code.:

Synonyms:(2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide

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Chemical Property of (2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide

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Technology Process of (2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide

There total 3 articles about (2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 119593-40-7
(4S,5S)-5-<(phenylsulfonyl)amino>-2,2-dimethyl-4-<3-(methylsulfonoxy)propyl>-1,3-dioxane

: 119593-41-8
(2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide

Guidance literature:: With calcined K₂CO₃; In methanol; for 4h; Ambient temperature;
DOI:10.1021/jo00269a023

Reference yield:

: 119593-27-0
(4S,5S)-5-<(phenylsulfonyl)amino>-4-allyl-2,2-dimethyl-1,3-dioxane

: 119593-41-8
(2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BH₃*THF, 2.) 30percent H₂O₂, 3 M NaOH / 1.) THF, RT, 1 h, 2.) THF, 45 deg C, 0.5 h

2: 92 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: 100 percent / calcined K₂CO₃ / methanol / 4 h / Ambient temperature

With sodium hydroxide; borane-THF; calcined K₂CO₃; dihydrogen peroxide; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo00269a023

Reference yield:

: 119593-39-4
(4S,5S)-5-<(phenylsulfonyl)amino>-2,2-dimethyl-4-(3-hydroxypropyl)-1,3-dioxane

: 119593-41-8
(2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine acetonide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: 100 percent / calcined K₂CO₃ / methanol / 4 h / Ambient temperature

With calcined K₂CO₃; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo00269a023