1-(Phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane

Base Information

Chemical Name:1-(Phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane
CAS No.:117095-64-4
Molecular Formula:C26H28 Cl N O2
Molecular Weight:421.96
Hs Code.:
ChEMBL ID:CHEMBL291809
Mol file:117095-64-4.mol

Synonyms:1-(phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane;2,4-P-clomiphene

Suppliers and Price of 1-(Phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-(Phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane

Chemical Property:

Vapor Pressure:2.61E-12mmHg at 25°C
Boiling Point:540.8°Cat760mmHg
Flash Point:280.9°C
PSA：32.70000
Density:1.152g/cm³
LogP:6.22480
XLogP3:6.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:421.1808568
Heavy Atom Count:30
Complexity:511

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)O)Cl)C3=CC=CC=C3
Isomeric SMILES:CCN(CC)CCOC1=CC=C(C=C1)/C(=C(\C2=CC=C(C=C2)O)/Cl)/C3=CC=CC=C3

Technology Process of 1-(Phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane

There total 4 articles about 1-(Phenyl)-1-(4-(2-(diethylamino)-ethoxy)phenyl)-2-(4-hydroxyphenyl)-2-chloroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117095-60-0
1-<4-<2-(diethylamino)ethoxy>phenyl>-1-phenyl-2-<4-(benzyloxy)phenyl>-2-chloroethene

: 117095-64-4
4-{(E)-1-Chloro-2-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-vinyl}-phenol

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 2h; under 1034.3 Torr;
DOI:10.1021/jm00121a035

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 117095-64-4
4-{(E)-1-Chloro-2-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-vinyl}-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / 1) TiCl₄, Zn / tetrahydrofuran / 1) reflux, 2 h, 2) r.t.

2: 65 percent / N-chlorosuccinimide / CHCl₃ / 3 h / Heating

3: H₂ / 10percent Pd/C / acetic acid / 2 h / 1034.3 Torr

With N-chloro-succinimide; hydrogen; titanium tetrachloride; zinc; palladium on activated charcoal; In tetrahydrofuran; chloroform; acetic acid;
DOI:10.1021/jm00121a035

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 117095-64-4
4-{(E)-1-Chloro-2-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-vinyl}-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH / 1) DMF, 2) 125 deg C, 4 h

2: 49 percent / 1) TiCl₄, Zn / tetrahydrofuran / 1) reflux, 2 h, 2) r.t.

3: 65 percent / N-chlorosuccinimide / CHCl₃ / 3 h / Heating

4: H₂ / 10percent Pd/C / acetic acid / 2 h / 1034.3 Torr

With N-chloro-succinimide; hydrogen; titanium tetrachloride; sodium hydride; zinc; palladium on activated charcoal; In tetrahydrofuran; chloroform; acetic acid;
DOI:10.1021/jm00121a035