(R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride

Base Information

Chemical Name:(R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride
CAS No.:118792-40-8
Molecular Formula:C₁₉H₂₉N₃O₃*ClH
Molecular Weight:383.918
Hs Code.:

Synonyms:(R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride

Chemical Property:

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Technology Process of (R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride

There total 6 articles about (R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118792-34-0
{(R)-1-[(R)-1-(4-Acetyl-phenylcarbamoyl)-2-methyl-propylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

: 118792-40-8
(R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1248/cpb.36.3119

Reference yield:

: 1685-33-2
N-[(benzyloxy)carbonyl]-D-valine

: 118792-40-8
(R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / PCl₃, pyridine / Ambient temperature

2: 25percent HBr-AcOH

3: 81 percent / HOBt, DCC, Et₃N / dimethylformamide / 4 °C

4: 7.3N HCl / dioxane

With pyridine; hydrogenchloride; hydrogen bromide; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; phosphorus trichloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.3119

Reference yield:

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: 118792-40-8
(R)-2-Amino-4-methyl-pentanoic acid [(R)-1-(4-acetyl-phenylcarbamoyl)-2-methyl-propyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / HOBt, DCC, Et₃N / dimethylformamide / 4 °C

2: 7.3N HCl / dioxane

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.3119