Technology Process of (2R)-N-(3-(1,5-dioxaspiro[5.5]undecan-7-yl)propyl)-2-phenylbut-3-en-1-amine
There total 11 articles about (2R)-N-(3-(1,5-dioxaspiro[5.5]undecan-7-yl)propyl)-2-phenylbut-3-en-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 - 22 ℃;
for 22h;
Inert atmosphere;
DOI:10.1021/jo4018099
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium hydroxide / methanol / 80 °C / Inert atmosphere
2: diphenylphosphoranyl azide; triethylamine / 85 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 0 - 22 °C / Inert atmosphere
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 21 h / 22 °C / Inert atmosphere
5: lithium aluminium tetrahydride / diethyl ether / 22 h / 0 - 22 °C / Inert atmosphere
With
dmap; lithium aluminium tetrahydride; diphenylphosphoranyl azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium hydroxide;
In
methanol; diethyl ether; dichloromethane;
2: |Curtius Rearrangement;
DOI:10.1021/jo4018099
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 0 - 22 °C / Inert atmosphere
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 21 h / 22 °C / Inert atmosphere
3: lithium aluminium tetrahydride / diethyl ether / 22 h / 0 - 22 °C / Inert atmosphere
With
dmap; lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
diethyl ether; dichloromethane;
DOI:10.1021/jo4018099