(2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene

Base Information

Chemical Name:(2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene
CAS No.:174531-90-9
Molecular Formula:C₃₁H₃₉NO₆Si
Molecular Weight:549.739
Hs Code.:

Synonyms:(2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene

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Chemical Property of (2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene

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Technology Process of (2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene

There total 4 articles about (2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42075-32-1
(2R,4R)-pentanediol

: 174531-90-9
(2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene

Guidance literature:: Multi-step reaction with 4 steps

1: PhI(OAc)2 / CH₂Cl₂ / 0.25 h / 21 °C

2: 23.2 mg / PPTS / benzene; tetrahydrofuran / 4 h / 65 °C

3: 49 percent / H₂O₂, K₂CO₃ / H₂O; tetrahydrofuran / 6 h / 21 °C

4: 1.) NaBH₄, 2.) imidazole / 1.) CH₃OH, -20 deg C, 30 min, 2.) CH₂Cl₂, 21 deg C, 4 h

With 1H-imidazole; sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; dihydrogen peroxide; pyridinium p-toluenesulfonate; potassium carbonate; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1055/s-1995-4141

Reference yield:

: 174531-87-4
(2R,4R)-7-<(allyloxycarbonyl)amino>-2,4-dimethyl-1,5-dioxaspiro<5.5>nona-7,10-dien-9-one

: 174531-90-9
(2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / H₂O₂, K₂CO₃ / H₂O; tetrahydrofuran / 6 h / 21 °C

2: 1.) NaBH₄, 2.) imidazole / 1.) CH₃OH, -20 deg C, 30 min, 2.) CH₂Cl₂, 21 deg C, 4 h

With 1H-imidazole; sodium tetrahydroborate; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; water;
DOI:10.1055/s-1995-4141

Reference yield:

: [6-((1R,3R)-3-Hydroxy-1-methyl-butoxy)-6-methoxy-3-oxo-cyclohexa-1,4-dienyl]-carbamic acid allyl ester

: 174531-90-9
(2R,4R,7S,8R,9S)-11-<(allyloxycarbonyl)amino>-9-(tert-butyldiphenylsilyloxy)-7,8-epoxy-2,4-dimethyl-1,5-dioxaspiro<5.5>non-10-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 23.2 mg / PPTS / benzene; tetrahydrofuran / 4 h / 65 °C

2: 49 percent / H₂O₂, K₂CO₃ / H₂O; tetrahydrofuran / 6 h / 21 °C

3: 1.) NaBH₄, 2.) imidazole / 1.) CH₃OH, -20 deg C, 30 min, 2.) CH₂Cl₂, 21 deg C, 4 h

With 1H-imidazole; sodium tetrahydroborate; dihydrogen peroxide; pyridinium p-toluenesulfonate; potassium carbonate; In tetrahydrofuran; water; benzene;
DOI:10.1055/s-1995-4141