[(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

Base Information

Chemical Name:[(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
CAS No.:1293940-84-7
Molecular Formula:C₁₅H₁₆FN₅O
Molecular Weight:301.323
Hs Code.:

Synonyms:[(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

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Chemical Property of [(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

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Technology Process of [(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

There total 3 articles about [(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293940-88-1
tert-butyl (1S,6R)-8-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate

: 1293940-84-7
[(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

Guidance literature:: tert-butyl (1S,6R)-8-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate; With trifluoroacetic acid; In dichloromethane; for 3h;

With sodium carbonate; In water;

Reference yield:

: 1293940-99-4
tert-butyl (1R,6S)-8-(1(S)-phenylethyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate

: 1293940-84-7
[(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; acetic acid / 20% palladium(II) hydroxide on carbon / ethanol / 16 h / 50 °C / 75007.5 Torr

2: triethylamine / dichloromethane

3: trifluoroacetic acid / dichloromethane / 3 h

With hydrogen; acetic acid; triethylamine; trifluoroacetic acid; 20% palladium(II) hydroxide on carbon; In ethanol; dichloromethane;

Reference yield:

: 1293284-51-1
3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

: 1293940-84-7
[(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl][3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

2: triethylamine / dichloromethane

3: trifluoroacetic acid / dichloromethane / 3 h

With oxalyl dichloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;