2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

Base Information

Chemical Name:2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide
CAS No.:1318769-15-1
Molecular Formula:C₂₇H₃₁N₃O₂
Molecular Weight:429.562
Hs Code.:

Synonyms:2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

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Chemical Property of 2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

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Technology Process of 2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

There total 6 articles about 2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 102873-43-8
2-chloro-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

: 78190-32-6
1-<(4-Hydroxy-phenyl)-ethyl>-pyrrolidin

: 1318769-15-1
2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

Guidance literature:: 2-chloro-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

1-<(4-Hydroxy-phenyl)-ethyl>-pyrrolidin; In N,N-dimethyl-formamide; at 50 ℃; for 2h;
DOI:10.2174/157018010791163532

Reference yield:

: 28145-35-9
4-(2-chloroethyl)phenol

: 1318769-15-1
2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 2 h / 50 °C

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.2174/157018010791163532

Reference yield:

: 321-64-2
tacrin

: 1318769-15-1
2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-N-(1,2,3,4-tetrahydroacridin-9-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 110 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 2 h / 50 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.2174/157018010791163532