[3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol

Base Information

• Chemical Name: [3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol
• CAS No.: 481070-05-7
• Molecular Formula: C₁₆H₁₃BrN₂S
• Molecular Weight: 345.263
• Mol file: 481070-05-7.mol

Synonyms:[3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol

Chemical Property of [3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol

There total 2 articles about [3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-[3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethyl]-isothiourea; hydrochloride → [3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol (481070-05-7)

Guidance literature:

With sodium hydroxide; In ethanol; at 75 - 80 ℃; for 3h;

DOI:10.1023/A:1016567727116

Reference yield:

4-(chloromethyl)-3-(4-bromophenyl)-1-phenyl-1H-pyrazole (372107-20-5) → [3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol (481070-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 0.5 h / Heating

2: 78 percent / 10 percent aq. NaOH / ethanol / 3 h / 75 - 80 °C

With sodium hydroxide; In tetrahydrofuran; ethanol;

DOI:10.1023/A:1016567727116

Reference yield: 73.0%

chloroacetic acid (79-11-8) + [3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-methanethiol (481070-05-7) → 3-(4-bromophenyl)-1-phenyl-4-pyrazolylmethylsulfanylacetic acid (930303-89-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1134/S1070428006050101

upstream raw materials:

4-(chloromethyl)-3-(4-bromophenyl)-1-phenyl-1H-pyrazole

Downstream raw materials:

3-(4-bromophenyl)-1-phenyl-4-pyrazolylmethylsulfanylacetic acid