4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

Base Information

Chemical Name:4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol
CAS No.:1271132-09-2
Molecular Formula:C₃₁H₃₆N₄O₇
Molecular Weight:576.649
Hs Code.:

Synonyms:4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

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Chemical Property of 4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

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Technology Process of 4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

There total 1 articles about 4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4-(N-benzyloxycarbonylamino)-2-azido-3-O-chloroacetyl-2,4,6-trideoxy-α/β-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

: 1271132-62-7
4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-β-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

: 1271132-09-2
4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

Guidance literature:: With pyridine; thiourea; In ethanol; at 65 ℃; for 3h;
DOI:10.1021/jo102363d

Reference yield: 70.0%

: 853646-67-0
phenyl 2,4-di-O-benzyl-1-thio-β-D-galactopyranosidurono-6,3-lactone

: 1271132-09-2
4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

: 1271132-47-8
2,4-di-O-benzyl-α-D-galactopyranosiduronyl-3,6-lactone-(1->3)-4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-di-O-benzyl-sn-glycerol

Guidance literature:: phenyl 2,4-di-O-benzyl-1-thio-β-D-galactopyranosidurono-6,3-lactone; With 1,1'-sulfinylbisbenzene; 2,4,6-tri-tert-butylpyrimidine; In dichloromethane; for 0.5h; Molecular sieve;

With trifluoromethylsulfonic anhydride; In dichloromethane; at -60 - -45 ℃;

4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol; With 2,4,6-tri-tert-butylpyrimidine; In dichloromethane; at -60 - -45 ℃; diastereoselective reaction;
DOI:10.1021/jo102363d

Reference yield:

: 1271132-09-2
4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-O-benzyl-sn-glycerol

: 1271132-50-3
benzyl 2,4-di-O-benzyl-α-D-galactopyranosyluronate-(1->3)-4-(N-benzyloxycarbonylamino)-2-azido-2,4,6-trideoxy-α-D-galactopyranosyl-(1->3)-1,2-di-O-benzyl-sn-glycerol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-sulfinylbisbenzene; 2,4,6-tri-tert-butylpyrimidine / dichloromethane / 0.5 h / Molecular sieve

1.2: -60 - -45 °C

1.3: -60 - -45 °C

2.1: sodium trimethylsilanolate / dichloromethane / 0.83 h

3.1: caesium carbonate / N,N-dimethyl-formamide / Inert atmosphere

With 1,1'-sulfinylbisbenzene; sodium trimethylsilanolate; caesium carbonate; 2,4,6-tri-tert-butylpyrimidine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo102363d