(E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

Base Information

Chemical Name:(E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid
CAS No.:1185753-65-4
Molecular Formula:C₂₅H₂₃BrF₃NO₃
Molecular Weight:522.362
Hs Code.:

Synonyms:(E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

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Chemical Property of (E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

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Technology Process of (E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

There total 5 articles about (E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1184721-52-5
(+/-)-(E)-ethyl 2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetate

: 1185753-65-4
(E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

Guidance literature:: With lithium hydrochloride monohydrate; water; In methanol; at 20 ℃; for 8h; Product distribution / selectivity;

Reference yield:

: 1009375-03-4
tert-butyl 7-bromo-3-(2-ethoxy-2-oxoethyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

: 1185753-65-4
(E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2.1: MP-carbonate resin / dichloromethane / 0.5 h

2.2: 4 h / 20 °C

3.1: lithium hydrochloride monohydrate; water / methanol / 8 h / 20 °C

With MP-carbonate resin; lithium hydrochloride monohydrate; water; trifluoroacetic acid; In methanol; dichloromethane;

Reference yield:

: 1184721-36-5
ethyl 2-(7-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetate trifluoroacetate salt

: 1185753-65-4
(E)-2-(7-bromo-1'-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: MP-carbonate resin / dichloromethane / 0.5 h

1.2: 4 h / 20 °C

2.1: lithium hydrochloride monohydrate; water / methanol / 8 h / 20 °C

With MP-carbonate resin; lithium hydrochloride monohydrate; water; In methanol; dichloromethane;