(S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

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Chemical Name:(S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid
CAS No.:1612783-59-1
Molecular Formula:C₂HF₃O₂*C₂₅H₃₆FN₇O₅
Molecular Weight:647.627
Hs Code.:

(S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

Synonyms:(S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

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Chemical Property of (S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

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Technology Process of (S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

There total 4 articles about (S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612783-56-8
C₂₂H₂₇ClFN₅O₅

: 109-76-2,54018-94-9
Trimethylenediamine

: 76-05-1
trifluoroacetic acid

: 1612783-59-1
(S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

Guidance literature:: C₂₂H₂₇ClFN₅O₅; Trimethylenediamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; isopropyl alcohol; at 20 - 45 ℃; for 2h;

trifluoroacetic acid;

Reference yield:

: 2972-52-3
2,4-dichloropyrimidine-5-carbonyl chloride

: 1612783-59-1
(S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; N,N-dimethyl-formamide / 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; N,N-dimethyl-formamide / 2 h / 20 - 45 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 140-75-0
para-fluorobenzylamine

: 1612783-59-1
(S)-5-((2-((3-aminopropyl)amino)-5-((4-fluorobenzyl)carbamoyl)pyrimidin-4-yl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; N,N-dimethyl-formamide / 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; N,N-dimethyl-formamide / 2 h / 20 - 45 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;