N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

Base Information

Chemical Name:N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate
CAS No.:173677-68-4
Molecular Formula:C₂₈H₂₉NO₅
Molecular Weight:459.542
Hs Code.:

N-<2-(6,11-dihydro-11-oxodibenz<b,e>oxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

Synonyms:N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

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Chemical Property of N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

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Technology Process of N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

There total 7 articles about N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 79722-21-7
tert-butyl N-(benzyloxy)carbamate

: 94128-29-7
2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)-ethanol methanesulfonate

: 173677-68-4
N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃;
DOI:10.1021/jm950563z

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 173677-68-4
N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃, KI / butan-2-one / 24 h / Heating

2: KOH / aq. ethanol / Heating

3: 1.) (CF₃CO)2O, 2.) 10percent aq. HCl / 1.) CH₂Cl₂, reflux, 4 h, 2.) acetone, reflux, 24 h

4: 59 percent / borane / tetrahydrofuran / 72 h / Ambient temperature

5: Et₃N

6: 54 percent / NaH / dimethylformamide / 100 °C

With hydrogenchloride; potassium hydroxide; borane; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic anhydride; potassium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm950563z

Reference yield:

: 55453-87-7
isoxepac

: 173677-68-4
N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / borane / tetrahydrofuran / 72 h / Ambient temperature

2: Et₃N

3: 54 percent / NaH / dimethylformamide / 100 °C

With borane; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm950563z