2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine

Base Information

• Chemical Name: 2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine
• CAS No.: 1374217-73-8
• Molecular Formula: C₁₄H₉Cl₂N₃S
• Molecular Weight: 322.218
• Mol file: 1374217-73-8.mol

Synonyms:2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine

Chemical Property of 2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine

There total 1 articles about 2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-methoxy-3-phenyl-2-propenoate (72050-17-0,72050-18-1,7759-03-7) → 2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine (1374217-73-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2.5 h / 140 °C / Microwave irradiation

1.2: 1.2 h / 250 °C / Microwave irradiation

2.1: trichlorophosphate / 1.5 h / 200 °C / Microwave irradiation

3.1: tetrahydrofuran / 3 h / -10 °C

With trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/jo300189q

Reference yield: 78.0%

2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine (1374217-73-8) + phenylboronic acid (98-80-6) → 2,8-dichloro-4,6-diphenylpyrido[3,2-d]pyrimidine (1374217-75-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; In 1,4-dioxane; at 110 ℃; for 1.5h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/jo300189q

Reference yield:

2,8-dichloro-4-methylsulfanyl-6-phenylpyrido[3,2-d]pyrimidine (1374217-73-8) + phenylboronic acid (98-80-6) → 2-benzylsulfanyl-4,6-diphenyl-8-chloropyrido[3,2-d]pyrimidine (1374217-91-0) + 2-chloro-4,6-diphenyl-8-benzylsulfanylpyrido[3,2-d]pyrimidine (1374217-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate / 1,4-dioxane / 1.5 h / 110 °C / Microwave irradiation; Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; acetonitrile / 1 h / 90 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile; 1: Liebeskind-Srogl cross-coupling reaction;

DOI:10.1021/jo300189q

upstream raw materials:

ethyl 3-methoxy-3-phenyl-2-propenoate

Downstream raw materials:

2,8-dichloro-4,6-diphenylpyrido[3,2-d]pyrimidine

2-benzylsulfanyl-4,6-diphenyl-8-chloropyrido[3,2-d]pyrimidine

2-chloro-4,6-diphenyl-8-benzylsulfanylpyrido[3,2-d]pyrimidine