(R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one

Base Information

Chemical Name:(R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one
CAS No.:1027555-16-3
Molecular Formula:C₁₄H₁₀F₄N₆O₂
Molecular Weight:370.266
Hs Code.:

Synonyms:(R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one

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Chemical Property of (R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one

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Technology Process of (R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one

There total 6 articles about (R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid (R)-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl ester

: 1027555-16-3
(R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 65 ℃;
DOI:10.1021/jm990373e

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1027555-16-3
(R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / dimethylsulfoxide / 90 °C

2.1: H₂ / 10percent Pd/C / methanol / 3 h / 1034.32 Torr

3.1: NaHCO₃ / tetrahydrofuran / 0 - 20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

4.2: tetrahydrofuran / -78 - 20 °C

5.1: NEt₃ / CH₂Cl₂ / 4 h / 20 °C

6.1: NaN₃ / dimethylformamide / 65 °C

With sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Ring cleavage / 5.1: mesylation / 6.1: Substitution;
DOI:10.1021/jm990373e

Reference yield:

: 266327-61-1
3-fluoro-1-nitro-4-(1H-3-trifluoromethyl-pyrazol-1-yl)benzene

: 1027555-16-3
(R)-5-Azidomethyl-3-[3-fluoro-4-(3-trifluoromethyl-pyrazol-1-yl)-phenyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / 10percent Pd/C / methanol / 3 h / 1034.32 Torr

2.1: NaHCO₃ / tetrahydrofuran / 0 - 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

3.2: tetrahydrofuran / -78 - 20 °C

4.1: NEt₃ / CH₂Cl₂ / 4 h / 20 °C

5.1: NaN₃ / dimethylformamide / 65 °C

With sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: Acylation / 3.1: Metallation / 3.2: Ring cleavage / 4.1: mesylation / 5.1: Substitution;
DOI:10.1021/jm990373e