C₂₈H₂₆N₂O₂

Base Information

• Chemical Name: C₂₈H₂₆N₂O₂
• CAS No.: 1320362-20-6
• Molecular Formula: C₂₈H₂₆N₂O₂
• Molecular Weight: 422.527
• Mol file: 1320362-20-6.mol

Synonyms:C₂₈H₂₆N₂O₂

Chemical Property of C₂₈H₂₆N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₆N₂O₂

There total 4 articles about C₂₈H₂₆N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-iodo-1-methoxy-3-(p-tolyl)-1H-pyrano[4,3-b]quinoline (1256286-01-7) + 4-(dimethylamino)benzene-boronic acid (28611-39-4) → C28H26N2O2 (1320362-20-6)

Guidance literature:

With trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/co200100z

Reference yield:

2-chloro-3-quinoline carboxaldehyde (73568-25-9) → C28H26N2O2 (1320362-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 60 °C

2: iodine; potassium carbonate / dichloromethane / 2 h / 20 °C

3: trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; 1: Sonogashira coupling / 3: Suzuki coupling;

DOI:10.1021/co200100z

Reference yield:

2-(2-(p-tolyl)ethynyl)quinoline-3-carbaldehyde (1159765-59-9) → C28H26N2O2 (1320362-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; potassium carbonate / dichloromethane / 2 h / 20 °C

2: trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;

DOI:10.1021/co200100z

upstream raw materials:

2-(2-(p-tolyl)ethynyl)quinoline-3-carbaldehyde

4-iodo-1-methoxy-3-(p-tolyl)-1H-pyrano[4,3-b]quinoline

4-(dimethylamino)benzene-boronic acid

2-chloro-3-quinoline carboxaldehyde