tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

Base Information

• Chemical Name: tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate
• CAS No.: 1263321-93-2
• Molecular Formula: C₁₄H₁₆FNO₃
• Molecular Weight: 265.284
• Mol file: 1263321-93-2.mol

Synonyms:tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

Chemical Property of tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

There total 2 articles about tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-fluorobenzaldehyde (459-57-4) + tert-Butyl isocyanoacetate (2769-72-4) → tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate (1263321-93-2) + tert-butyl 5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

Guidance literature:

With N-[(9R)-10,11-dihydrocinchonan-9-yl]-2-(diphenylphosphino)benzamide; silver(l) oxide; In ethyl acetate; at -20 ℃; optical yield given as %de; stereoselective reaction; Molecular sieve;

DOI:10.1021/ja110534g

Reference yield:

4-fluorobenzaldehyde (459-57-4) + tert-Butyl isocyanoacetate (2769-72-4) → tert-butyl (4S,5R)-5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate (1263321-93-2) + tert-butyl 5-(4-fluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate + t-butyl (4R,5S)-5-(4-fluorophenyl)-4,5-dihydrooxazole-4-carboxylate

Guidance literature:

With potassium phosphate; C₄₂H₃₃F₁₂N₂O⁽¹⁺⁾*Br^(1-); In toluene; at -30 ℃; for 40h; stereoselective reaction;

DOI:10.3184/174751916X14683198156665

upstream raw materials:

4-fluorobenzaldehyde

tert-Butyl isocyanoacetate