(2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione

Base Information

Chemical Name:(2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione
CAS No.:1237025-13-6
Molecular Formula:C₃₀H₂₈BrNO₄
Molecular Weight:546.461
Hs Code.:

Synonyms:(2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione

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Chemical Property of (2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione

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Technology Process of (2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione

There total 1 articles about (2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1237025-10-3
(2R,3S,Z)-6-(4-(3-bromobenzyloxy)benzylidene)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione

: 16466-97-0,13254-27-8
1-propynylmagnesium bromide

: 1237025-13-6
(2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione

Guidance literature:: (2R,3S,Z)-6-(4-(3-bromobenzyloxy)benzylidene)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione; 1-propynylmagnesium bromide; In tetrahydrofuran; at -45 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.019

Reference yield:

: 1237025-13-6
(2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione

: C₃₀H₃₀BrNO₅

Guidance literature:: (2R,3S)-6-((S)-1-(4-(3-bromobenzyloxy)phenyl)but-2-ynyl)-3,4-dimethyl-2-phenyl-1,4-oxazepane-5,7-dione; With tetra(n-butyl)ammonium hydroxide; water; In tert-butyl alcohol; at 20 ℃; for 16h; Inert atmosphere;

With ammonium chloride; In water; tert-butyl alcohol; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.019