N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Base Information

Chemical Name:N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide
CAS No.:1617522-84-5
Molecular Formula:C₂₀H₁₉F₂N₃O₄
Molecular Weight:403.385
Hs Code.:

Synonyms:N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

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Chemical Property of N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

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Technology Process of N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

There total 4 articles about N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1617523-36-0
C₂₀H₁₇F₂N₃O₄

: 1617522-84-5
N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With methanol; sodium tetrahydroborate; at 23 ℃; for 0.333333h;

Reference yield:

: 51985-95-6
methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

: 1617522-84-5
N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 0 - 120 °C

2: cesium fluoride; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 4 h / 85 °C / Inert atmosphere

3: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 2 h / 60 °C

4: sodium tetrahydroborate; methanol / 0.33 h / 23 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; cesium fluoride; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane;

Reference yield:

: 321848-41-3
C₇H₇ClN₂O₃

: 1617522-84-5
N-(2,6-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-4-(hydroxymethyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 4 h / 85 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 2 h / 60 °C

3: sodium tetrahydroborate; methanol / 0.33 h / 23 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; cesium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; hexane;