methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate

Base Information

• Chemical Name: methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate
• CAS No.: 1198111-59-9
• Molecular Formula: C₁₆H₁₁FN₂O₃
• Molecular Weight: 298.273
• Mol file: 1198111-59-9.mol

Synonyms:methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate

Chemical Property of methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate

There total 1 articles about methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

methyl 3-formyl-1H-indazole-4-carboxylate (433728-79-1) + 4-fluoroboronic acid (1765-93-1) → methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate (1198111-59-9)

Guidance literature:

With triethylamine; copper diacetate; In dichloromethane; at 20 ℃; for 21h; Product distribution / selectivity;

Reference yield:

methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate (1198111-59-9) + (3R)-quinuclidin-3-amine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5) → C23H23FN4O2

Guidance literature:

(3R)-quinuclidin-3-amine dihydrochloride; With sodium hydride; In dichloromethane;

With acetic acid; In dichloromethane;

methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

methyl 3-formyl-1-(4-fluorophenyl)-1H-indazole-4-carboxylate (1198111-59-9) + (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5) → (S)-methyl 1-(4-fluorophenyl)-3-[(quinuclidin-3-ylamino)methyl]-1H-indazole-4-carboxylate (1198111-60-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2010.11.080

upstream raw materials:

methyl 3-formyl-1H-indazole-4-carboxylate

4-fluoroboronic acid

Downstream raw materials:

(S)-methyl 1-(4-fluorophenyl)-3-[(quinuclidin-3-ylamino)methyl]-1H-indazole-4-carboxylate