Norchelerythrine

Base Information

• Chemical Name: Norchelerythrine
• CAS No.: 6900-99-8
• Molecular Formula: C20H15NO4
• Molecular Weight: 333.343
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50219044
• Nikkaji Number: J116.962I
• Wikidata: Q27114717
• Metabolomics Workbench ID: 69840
• ChEMBL ID: CHEMBL1182694
• Mol file: 6900-99-8.mol

Synonyms:chelerythrine;chelerythrine chloride;chelerythrine hydroxide;chelerythrine sulfate;norchelerythrine

Chemical Property of Norchelerythrine

Chemical Property:

• Vapor Pressure: 9.27E-12mmHg at 25°C
• Melting Point: 221.5-222.5 °C
• Boiling Point: 554.3°C at 760 mmHg
• PKA: 3.84±0.20(Predicted)
• Flash Point: 194.2°C
• PSA: 49.81000
• Density: 1.365g/cm³
• LogP: 4.28710
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 333.10010796
• Heavy Atom Count: 25
• Complexity: 488

Purity/Quality:

> 95% ^*data from raw suppliers

Norchelerythrine(NewProduct) 98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C2=CN=C3C(=C2C=C1)C=CC4=CC5=C(C=C43)OCO5)OC

Technology Process of Norchelerythrine

There total 52 articles about Norchelerythrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

11,12-dihydro-7,8-dimethoxy-2,3-methylenedioxybenzo[c]phenanthridine (1268827-93-5) → norchelerythrine (6900-99-8)

Guidance literature:

With palladium 10% on activated carbon; In 1,2-dichloro-benzene; at 180 ℃;

DOI:10.1016/j.tet.2010.11.066

Reference yield: 86.0%

(4bS,11bR)-1,2-dimethoxy-4b,11b-dihydro[1,3]dioxolo-[4′,5′:4,5]benzo[1,2-c]phenanthridine → norchelerythrine (6900-99-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.joc.1c01612

Reference yield: 62.0%

2-{6-[(7,8-dimethoxyisoquinolin-3-yl)]benzo[d][1,3]-dioxol-5-yl}ethanol → norchelerythrine (6900-99-8)

Guidance literature:

2-{6-[(7,8-dimethoxyisoquinolin-3-yl)]benzo[d][1,3]-dioxol-5-yl}ethanol; With sodium hydroxide; In dimethyl sulfoxide; at 130 ℃; Inert atmosphere;

In dimethyl sulfoxide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c04310

upstream raw materials:

4-methylisopropylbenzene

13-chloro-1,2-dimethoxy-5,6-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine

diazomethane

decarine

Downstream raw materials:

chelerythrine chloride

oxychelerythrine