1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione

Base Information

Chemical Name:1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione
CAS No.:1229643-26-8
Molecular Formula:C₂₄H₂₆N₂O₆S₂
Molecular Weight:502.612
Hs Code.:

Synonyms:1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione

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Chemical Property of 1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione

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Technology Process of 1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione

There total 2 articles about 1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 96013-55-7
1-[(4-methylphenyl)sulfonyl]-5,6-dihydro-1H-piperidin-2-one

: (1RS,6SR,7RS)-2-oxo-3-[(4-methylphenyl)sulfonyl]-3-azabicyclo[4.1.0]heptane-7-carboxylic acid tert-butyl ester

: 1229643-26-8
1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione

Guidance literature:: bromoacetic acid tert-butyl ester; With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 20 ℃; for 1h;

1-[(4-methylphenyl)sulfonyl]-5,6-dihydro-1H-piperidin-2-one; With caesium carbonate; sodium iodide; In acetonitrile; at 80 ℃; for 48h;
DOI:10.1016/j.tetlet.2010.04.021

Reference yield: 57.0%

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 96013-55-7
1-[(4-methylphenyl)sulfonyl]-5,6-dihydro-1H-piperidin-2-one

: (1RS,6RS,7RS)-3-[(4-methylphenyl)sulfonyl]-7-(2,2,2-trifluoroacetyl)-3-azabicyclo[4.1.0]heptane-2-one

: 1229643-26-8
1,1'-bis[(4-methylphenyl)sulfonyl]-5,6,3',4',5',6'-hexahydro-1H,1'H-[3,4']bipyridinyl-2,2'-dione

Guidance literature:: 3-bromo-1,1,1-trifluoroacetone; With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 20 ℃; for 1h;

1-[(4-methylphenyl)sulfonyl]-5,6-dihydro-1H-piperidin-2-one; With caesium carbonate; sodium iodide; In acetonitrile; at 80 ℃; for 24h;
DOI:10.1016/j.tetlet.2010.04.021