2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide

Base Information

Chemical Name:2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide
CAS No.:153624-55-6
Molecular Formula:C₂₅H₃₃N₃O₅S
Molecular Weight:487.62
Hs Code.:

Synonyms:2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide

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Chemical Property of 2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide

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Technology Process of 2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide

There total 3 articles about 2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179251-19-5
2'-(2,2-dimethyl-1-oxo-1-propylamino)-N-(3,4-dimethyl-5-isoxazolyl)-N-<(2-methoxyethoxy)methyl>-4'-(2-methylpropyl)<1,1'-biphenyl>-2-sulfonamide

: 153624-55-6
2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 5h;
DOI:10.1021/jm970872k

Reference yield:

: 179250-70-5
2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

: 153623-88-2
3'-Amino-N-(3,4-dimethyl-5-isoxazolyl)[1,1'-biphenyl]-2-sulfonamide

: 153624-55-6
2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: In ethyl acetate;

Reference yield:

: 179251-18-4
2-(2,2-dimethyl-1-oxo-1-proylamino)-4-(2-methyl-1-propyl)phenylboronic acid

: 153624-55-6
2'-Amino-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / (Ph₃P)4Pd, aq. Na₂CO₃ / toluene; aq. ethanol / 3 h / 75 °C

2: diisobutylaluminum hydride / tetrahydrofuran; hexane / 5 h / -78 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisobutylaluminium hydride; sodium carbonate; In tetrahydrofuran; ethanol; hexane; toluene;
DOI:10.1021/jm970872k