4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester

Base Information

Chemical Name:4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester
CAS No.:562823-77-2
Molecular Formula:C₄₄H₃₅I₃O₂
Molecular Weight:976.474
Hs Code.:

Synonyms:4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester

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Chemical Property of 4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester

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Technology Process of 4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester

There total 4 articles about 4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 3034-86-4
4-ethynylbenzoic acid methyl ester

: 144970-30-9
1,3,5,7-tetrakis(4-iodophenyl)adamantane

: 562823-77-2
4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 10h;
DOI:10.1021/jo026923p

Reference yield:

: 619-58-9
4-iodobenzoic acid

: 562823-77-2
4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / K₂CO₃ / dimethylsulfoxide

2: 95 percent / Pd(PPh₃)2Cl₂; CuI; triethylamine / tetrahydrofuran / 1.5 h / 80 °C

3: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / -20 °C

4: 36 percent / Pd(PPh₃)2Cl₂; CuI; triethylamine / tetrahydrofuran / 10 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; 2: Sonogashira coupling / 4: Sonogashira coupling;
DOI:10.1021/jo026923p

Reference yield:

: 619-44-3
methyl 4-iodobenzoate

: 562823-77-2
4-[4-[3,5,7-tris(4-iodophenyl)adamantan-1-yl]phenylethynyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Pd(PPh₃)2Cl₂; CuI; triethylamine / tetrahydrofuran / 1.5 h / 80 °C

2: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / -20 °C

3: 36 percent / Pd(PPh₃)2Cl₂; CuI; triethylamine / tetrahydrofuran / 10 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1: Sonogashira coupling / 3: Sonogashira coupling;
DOI:10.1021/jo026923p