N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide

Base Information

• Chemical Name: N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide
• CAS No.: 1026754-33-5
• Molecular Formula: C₂₃H₂₈N₂O₅S
• Molecular Weight: 444.552
• Mol file: 1026754-33-5.mol

Synonyms:N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide

Chemical Property of N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide

There total 7 articles about N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide (1401355-74-5) → N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide (1026754-33-5)

Guidance literature:

With hydrogen; In methanol; at 25 ℃; for 24h; under 7500.75 Torr;

Reference yield: 82.0%

N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide (1401355-77-8) → N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide (1026754-33-5)

Guidance literature:

With sodium hydroxide; In methanol; for 3h; Reflux;

Reference yield:

(5-nitro-2-butylbenzofuran-3-yl)-[4-(2-cyanoethoxy)phenyl]methanone (1401355-76-7) → N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide (1026754-33-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 50 °C / 3750.38 Torr

2: pyridine / dichloromethane / 3.17 h / 30 - 35 °C

3: hydrogen / Raney-Ni / methanol / 24 h / 25 °C / 7500.75 Torr

With pyridine; hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane;

upstream raw materials:

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide

N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide

(5-amino-2-butylbenzofuran-3-yl)-[4-(2-cyanoethoxy)phenyl]methanone

Downstream raw materials:

dronedarone