Acetamide, N-(4-(((3,6-dihydro-4-(5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl)-1(2H)-pyridinyl)amino)sulfonyl)phenyl)-

Base Information

• Chemical Name: Acetamide, N-(4-(((3,6-dihydro-4-(5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl)-1(2H)-pyridinyl)amino)sulfonyl)phenyl)-
• CAS No.: 160857-62-5
• Molecular Formula: C₂₂H₂₃N₅O₄S
• Molecular Weight: 453.522
• DSSTox Substance ID: DTXSID70167013
• Nikkaji Number: J604.870F
• Wikidata: Q83036316
• Mol file: 160857-62-5.mol

Synonyms:160857-62-5;Acetamide, N-(4-(((3,6-dihydro-4-(5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl)-1(2H)-pyridinyl)amino)sulfonyl)phenyl)-;C22H23N5O4S;DTXSID70167013;C22-H23-N5-O4-S;LS-9200;N-[[1,2,3,6-Tetrahydro-4-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]pyridin]-1-yl]-4-(acetylamino)benzenesulfonamide

Chemical Property of Acetamide, N-(4-(((3,6-dihydro-4-(5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl)-1(2H)-pyridinyl)amino)sulfonyl)phenyl)-

Chemical Property:

• Density: 1.42g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 453.14707541
• Heavy Atom Count: 32
• Complexity: 783

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NN=C(O2)C3=CCN(CC3)NS(=O)(=O)C4=CC=C(C=C4)NC(=O)C

Technology Process of Acetamide, N-(4-(((3,6-dihydro-4-(5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl)-1(2H)-pyridinyl)amino)sulfonyl)phenyl)-

There total 6 articles about Acetamide, N-(4-(((3,6-dihydro-4-(5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl)-1(2H)-pyridinyl)amino)sulfonyl)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-{4-[1-p-Tolyl-meth-(E)-ylidene-hydrazinocarbonyl]-3,6-dihydro-2H-pyridin-1-ylsulfamoyl}-phenyl)-acetamide (160857-57-8) → N-{4-[4-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-3,6-dihydro-2H-pyridin-1-ylsulfamoyl]-phenyl}-acetamide (160857-62-5)

Guidance literature:

With lead dioxide; In acetic acid; for 6h; Yield given; Ambient temperature;

Reference yield:

4-methyl-benzaldehyde (104-87-0) → N-{4-[4-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-3,6-dihydro-2H-pyridin-1-ylsulfamoyl]-phenyl}-acetamide (160857-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: glacid acetic acid / methanol / Heating

2: lead dioxide / acetic acid / 6 h / Ambient temperature

With lead dioxide; acetic acid; In methanol; acetic acid;

Reference yield:

p-acetylamino-N-<4-methoxycarbonyl-1.2.5.6-tetrahydro-1-pyridyl>benzenesulphonamide (160857-54-5) → N-{4-[4-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-3,6-dihydro-2H-pyridin-1-ylsulfamoyl]-phenyl}-acetamide (160857-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 34 percent / hydrazine hydrate (99percent) / 5 h

2: glacid acetic acid / methanol / Heating

3: lead dioxide / acetic acid / 6 h / Ambient temperature

With hydrazine hydrate; lead dioxide; acetic acid; In methanol; acetic acid;

upstream raw materials:

N-(4-{4-[1-p-Tolyl-meth-(E)-ylidene-hydrazinocarbonyl]-3,6-dihydro-2H-pyridin-1-ylsulfamoyl}-phenyl)-acetamide

4-methyl-benzaldehyde

p-acetylamino-N-<4-methoxycarbonyl-1.2.5.6-tetrahydro-1-pyridyl>benzenesulphonamide

p-acetylamino-N-<4-(hydrazinocarbonyl)-1,2,5,6-tetrahydro-1-pyridyl>benzenesulphonamide